Synthetic Chemical Biology Core, a part of the Center for Chemical Biology of Infectious Diseases (CBID) and Center for Molecular Analysis of Disease Pathways (CMADP), strives to provide comprehensive synthetic chemistry capabilities to investigators under one roof.
The synthetic expertise of the core includes, but is not limited to, novel and commercially unavailable small molecules, fluorescent molecules and peptides. The core assists in identifying hits for medicinal chemistry optimization in infectious disease targets and provides synthesis capabilities for structure activity studies of said hits. The core staff will work with investigators to design and synthesis novel molecular probes to facilitate their research.
The SCB core encompasses the Purification and Analysis Laboratory (PAL) that provides purification, analysis and quality control of compounds via HPLC-MS.
The core facility houses zebrafish (Danio rerio) for research in chemical biology and drug discovery. In contrast to more expensive rodent models, the optical transparency of these animals make them more amenable to a wide variety of fluorescence-based assays. The core provides adult zebrafish and zebrafish embryos for interested investigators.
Services provided by the core:
- Novel and commercial unavailable small molecule synthesis
- Fluorescent molecule synthesis
- Peptide synthesis
- Design and synthesis of novel molecular probes
- Quality control and analysis of compounds
- Structure-activity relationship studies based on HTS campaigns
- Housing of adult zebrafish and zebrafish embryos